End-Stage Complications of Diabetic Neuropathy: Foot Ulceration

The role of autonomic neuropathy in diabetic foot ulceration.

In an attempt to define the role of autonomic neuropathy in the pathogenesis of diabetic foot ulcers, we have studied diabetic patients with and without ulcers, and a group of non-diabetic controls. A series of standard autonomic function tests have been compared with measurement of the Galvanic Skin Response (GSR). Patients with foot ulcers showed evidence of more severe somatic and autonomic ...

Management of Diabetic Foot Complications Other than Ulceration

Pharmacologic therapy for neuropathic pain – A number of medications have proved in randomized trials to be useful in the treatment of painful diabetic neuropathy. These medications include: Tricyclic antidepressants (amitriptyline, nortriptyline, imipramine); Anticonvulsants (gabapentin, pregablin, sodium valproate, lamotrigine); SSRI antidepressants; Opioids (oxycodone, morphine). All these d...

Muscle perfusion scan for prediction of anticipated diabetic foot ulceration

Introduction:We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99mTc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. T...

Issues with Diabetic Foot Ulceration

The majority of foot ulcers appear to result from minor trauma in the presence of sensory neuropathy. This best describes the critical triad most commonly seen in patients with diabetic foot ulcers: peripheral sensory neuropathy, deformity, and trauma. All three of these risk factors are present in 65% of diabetic foot ulcers. Calluses, edema, and peripheral vascular disease have also been iden...

Diabetic Foot Ulceration and Amputation